{ "_id": "6a1d43da1d7bb097a0a41ad0", "Package": "BLOQ", "Type": "Package", "Version": "0.1-2", "Date": "2025-05-05", "Title": "Methods to Impute and Analyze Data with BLOQ Observations", "Authors@R": "c(\nperson(\"Vahid\",\"Nassiri\", email = \"vahid.nassiri@openanalytics.eu\", role = \"cre\"),\nperson(\"Helen\", \"Barnett\", email= \"h.barnett@lancaster.ac.uk\", role = \"aut\"),\nperson(\"Helena\", \"Geys\", email= \"HGEYS@its.jnj.com\", role = \"aut\"),\nperson(\"Tom\", \"Jacobs\", email= \"TJACOBS1@its.jnj.com\", role = \"aut\"),\nperson(\"Thomas\", \"Jaki\", email= \"t.jaki@lancaster.ac.uk\", role = \"aut\"))", "Maintainer": "Vahid Nassiri ", "Description": "Provides methods for estimating the area under the\nconcentration versus time curve (AUC) and its standard error in\nthe presence of Below the Limit of Quantification (BLOQ)\nobservations. Two approaches are implemented: direct estimation\nusing censored maximum likelihood, and a two-step approach that\nfirst imputes BLOQ values using various methods and then\ncomputes the AUC using the imputed data. Technical details are\ndescribed in Barnett et al. (2020), \"Methods for\nNon-Compartmental Pharmacokinetic Analysis With Observations\nBelow the Limit of Quantification,\" Statistics in\nBiopharmaceutical Research.\n.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "RoxygenNote": "7.3.2", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-01 08:29:36 UTC", "User": "root" }, "Author": "Vahid Nassiri [cre], Helen Barnett [aut], Helena Geys [aut],\nTom Jacobs [aut], Thomas Jaki [aut]", "Repository": "https://vahidnassiri.r-universe.dev", "Date/Publication": "2025-05-05 16:43:09 UTC", "RemoteUrl": "https://github.com/cran/BLOQ", "RemoteRef": "HEAD", "RemoteSha": "95863d89b302ccaa881d4c9297b232fd94c438b7", "MD5sum": "7e2d581a656a88989fb7299ad8613b7d", "_user": "vahidnassiri", "_type": "src", "_file": "BLOQ_0.1-2.tar.gz", "_fileid": "cb5a50a41eff4bfd9ed409f2845f904cdd0ae0cda78197d471c1a9b58d6cad3b", "_filesize": 203492, "_sha256": "cb5a50a41eff4bfd9ed409f2845f904cdd0ae0cda78197d471c1a9b58d6cad3b", "_created": "2026-06-01T08:29:36.000Z", "_published": "2026-06-01T08:33:30.703Z", "_distro": "noble", "_jobs": [ { "job": 78814375432, "time": 114, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7326820152" }, { "job": 78814375485, "time": 109, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7326818771" }, { "job": 78814375431, "time": 182, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7326834989" }, { "job": 78814375481, "time": 203, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7326833670" }, { "job": 78814000322, "time": 150, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7326782615" }, { "job": 78814375444, "time": 107, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7326817723" }, { "job": 78814375469, "time": 91, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7326812789" }, { "job": 78814375436, "time": 75, "config": 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"vahidnassiri", "count": 3, "uuid": 43675437 } ], "_userbio": { "uuid": 43675437, "type": "user", "name": "Vahid Nassiri" }, "_downloads": { "count": 598, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/BLOQ" }, "_searchresults": 13, "_rbuild": "4.6.0", "_assets": [ "extra/BLOQ.html", "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "manual.pdf" ], "_realowner": "vahidnassiri", "_cranurl": false, "_releases": [ { "version": "0.1-0", "date": "2018-08-13" }, { "version": "0.1-1", "date": "2020-06-07" }, { "version": "0.1-2", "date": "2025-05-05" } ], "_exports": [ "estimateAUCandStdErr", "estimateAUCwithCMLperTimePoint", "estimateAUCwithFullCML", "estimateAUCwithMVNCML", "estimateAUCwithPairwiseCML", "imputeBLOQ", "imputeCML", "imputeConstant", "imputeKernelDensityEstimation", "imputeROS", "simulateBealModelFixedEffects", "simulateBealModelMixedEffects" ], "_help": [ { "page": "estimateAUCandStdErr", "title": "Estimate AUC and its standard error", "topics": [ "estimateAUCandStdErr" ] }, { "page": "estimateAUCwithCMLperTimePoint", "title": "estimate AUC with censored maximum likelihood per time point", "topics": [ "estimateAUCwithCMLperTimePoint" ] }, { "page": "estimateAUCwithFullCML", "title": "estimate AUC with Full censored maximum likelihood", "topics": [ "estimateAUCwithFullCML" ] }, { "page": "estimateAUCwithMVNCML", "title": "estimate AUC with multivariate normal censored maximum likelihood", "topics": [ "estimateAUCwithMVNCML" ] }, { "page": "estimateAUCwithPairwiseCML", "title": "estimate AUCwith pairwise censored maximum likelihood", "topics": [ "estimateAUCwithPairwiseCML" ] }, { "page": "imputeBLOQ", "title": "impute BLOQ's with various methods", "topics": [ "imputeBLOQ" ] }, { "page": "imputeCML", "title": "imputing BLOQ's using censored maximum likelihood", "topics": [ "imputeCML" ] }, { "page": "imputeConstant", "title": "imputing BLOQ's with a constant value", "topics": [ "imputeConstant" ] }, { "page": "imputeKernelDensityEstimation", "title": "imputing BLOQ's using kernel density estimation", "topics": [ "imputeKernelDensityEstimation" ] }, { "page": "imputeROS", "title": "imputing BLOQ's using regression on order statistics", "topics": [ "imputeROS" ] }, { "page": "simulateBealModelFixedEffects", "title": "simulate data from Beal model with fixed effects", "topics": [ "simulateBealModelFixedEffects" ] }, { "page": "simulateBealModelMixedEffects", "title": "simulate data from Beal model with fixed and random effects", "topics": [ "simulateBealModelMixedEffects" ] } ], "_rundeps": [ "digest", "generics", "lattice", "maxLik", "miscTools", "mvtnorm", "sandwich", "zoo" ], "_score": 1.1139433523068367, "_indexed": true, "_nocasepkg": "bloq", "_universes": [ "vahidnassiri" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.1-2", "date": "2026-06-01T08:31:29.000Z", "distro": "noble", "commit": 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